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KMID : 0882420050690000906
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Korean Journal of Medicine
2005 Volume.69 No. 0 p.906 ~ p.909
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A case of rabdomyolysis associated with simvastatin?clopidogrel combination therapy
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Kwon Yong-Soo
Kim Seung-Tae
Song Pil-Sang
Ryu Dong-Ryeol
Choi So-Yeon
Lee Jin-Young
Kim Duk-Kyung
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Abstract
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Simvastatin, the 3?hydroxy?3methylglutaryl coenzyme (HMG?CoA) reductase inhibitor is effective in reduction the risk of coronary event and are generally well tolerated. Rhabdomyolysis is uncommon complication of this drug. We describe a case of rhabdomyolysis associated with concomitant use of simvastatin and clopidogrel. Rhabdomyolysis occurred 30 days after clopidogrel added to a chronic stable dose of simvastatin, and resolved after discontinuation of simvastatin and
clopidogrel. We recommend careful monitoring when clopidogrel is given to patients receiving simvastatin.(Korean J Med 69:S906-S909, 2005)
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KEYWORD
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Rhabdomyolysis, Clopidogrel, Simvastatin
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